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Pain| Volume 23, ISSUE 7, P360-364, July 01, 2022

The genesis of pain

  • Mike Hudspith
    Affiliations
    Mike Hudspith PhD FFPMRCA is a Consultant in Pain Medicine and Honorary Associate Professor (MED) UEA, Norfolk and Norwich University Hospital, Norwich, UK. Conflict of Interest: non declared
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Published:May 21, 2022DOI:https://doi.org/10.1016/j.mpaic.2022.03.007
The genesis of pain
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      Abstract

      This article explores mechanisms that may generate pain as a multidimensional and embodied construct rather than a simple sensory state. Existing models of pain will be reviewed alongside dynamic functional imaging data and contemporary cognitive neuroscience principles, including Bayesian predictive processing, to provide a potential explanation of chronic pain states. The focus is upon an exploration of integrated cortico-limbic processing as opposed to peripheral and central sensitization.

      Keywords

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      Further reading

        • Baroso J.
        • Branco P.
        • Apkarian A.V.
        Brain mechanisms of chronic pain: critical role of translational approach.
        Transl Res. 2021; 238: 76-89
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        The theory of constructed emotion: an active inference account of interoception and categorization.
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        Surfing uncertainty.
        Oxford University Press, 2016
      4. Corns J. The Routledge handbook of philosophy of pain. Taylor & Francis, 2017
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        How do you feel? Interoception: the sense of the physiological condition of the body.
        Nat Rev Neurosci. 2002; 3: 655-666
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        Anaesth Intensive Care Med. 2019; 20: 419-425
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        Nat Neurosci. 2014; 17: 1304-1312
        • Nicholas M.
        • Vlaeyen J.
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        The IASP classification of chronic pain for ICD-11: chronic primary pain.
        Pain. 2019; 160: 28-37
        • Solms M.
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        How and why consciousness arises.
        J Conscious Stud. 2018; 25: 202-238
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      Article Info

      Publication History

      Published online: May 21, 2022
      Royal College of Anaesthetists CPD Skills Framework: Pain

      Identification

      DOI: https://doi.org/10.1016/j.mpaic.2022.03.007

      Copyright

      © 2022 Published by Elsevier Ltd.

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