Anaesthesia & intensive care medicine
Volume 11, Issue 3 , Pages 98-100 , March 2010

Systemic toxic effects of local anaesthetics

References 

  1. Major complications of central neuraxial block in the United Kingdom; The 3rd National Audit Project of the Royal College of Anaesthetists, January 2009.
  2. Peck TE, Hill SA, Williams M. Pharmacology for anaesthesia and intensive care. 2nd edn. Cambridge University Press; 2006;
  3. Picard J, Meek T. Lipid emulsion to treat overdose of local anaesthetic: the gift of the glob. Anaesthesia. 2006;61:107–109
  4. McClure JH. Ropivacaine. Br J Anaesth. 1996;76:300–307
  5. Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ. Pretreatment or resuscitation with a lipid infusion shifts the dose–response to bupivacaine-induced asystole in rats. Anaesthesiology. 1998;88:1071–1075
  6. Weinberg G, Ripper R, Feinstein DL, Hoffman W. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anaesth Pain Med. 2003;28:198–202
  7. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB. Successful use of a 20% lipid emulsion to resuscitate a patient after presumed bupivacaine-related cardiac arrest. Anaesthesiology. 2006;105:217–218
  8. Litz RJ, Popp M, Stehr SN, Koch T. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia. 2006;61:800–801
  9. Foxall G, McCahon R, Lamb J, Hardman JG, Bedforth NM. Levo-bupivacaine-induced seizures and cardiovascular collapse treated with intralipid. Anaesthesia. 2007;62:516–518

PII: S1472-0299(09)00311-7

doi: 10.1016/j.mpaic.2009.12.003

Anaesthesia & intensive care medicine
Volume 11, Issue 3 , Pages 98-100 , March 2010