Anaesthesia & intensive care medicine
Volume 10, Issue 2 , Pages 98-101 , February 2009

The ethics of clinical trials

References 

  1. Beauchamp T, Childress J. Principles of biomedical ethics. 4th edn. Oxford: Oxford University Press; 1994;546
  2. Singh BN, Connolly SJ, Crijns HJGM, et al. Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter. N Engl J Med. 2007;357:987–999
  3. Ezekowitz MD. Maintaining sinus rhythm: making treatment better than the disease. N Engl J Med. 2007;357:1039–1041
  4. Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358:111–124
  5. Lièvre M, Menard J, Bruckert E, et al. Premature discontinuation of clinical trial for reasons not related to efficacy, safety, or feasibility. Commentary: early discontinuation violates Helsinki principles. BMJ. 2001;322:603–606
  6. Mythen MG, Soni N. Industry sponsorship. In:  Ridley SA editors. Ethical issues in intensive care. London: Intensive Care Society; 2007;p. 94–110
  7. Turner EH, Matthews AM, Linardatos E, et al. Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med. 2008;358:252–260
  8. Kastelein JJP, Akdim F, Stroes ESG, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med. 2008;358:1431–1443
  9. Lenzer J. Unreported cholesterol drug data released by companies show drug is ineffective. BMJ. 2008;336:180–181
  10. Groves T. Mandatory disclosure of trial results for drugs and devices. BMJ. 2008;336:170
  11. Gammon BD, Gunarathne A. It’s time to reappraise recruitment of South Asians to clinical trials. BMJ. 2008;336:46

PII: S1472-0299(08)00234-8

doi: 10.1016/j.mpaic.2008.10.001

Anaesthesia & intensive care medicine
Volume 10, Issue 2 , Pages 98-101 , February 2009

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