Measurement of respiratory function: ventilation

Abstract 

Measurement of ventilatory function is often impeded by poor technique when individuals perform tests of respiratory function. Static lung volumes (with the exception of residual volume and other capacities that contain residual volume) can be easily measured with spirometry. Residual volume and functional residual capacity can be measured using helium dilution or body plethysmography, although neither of these techniques are used in daily clinical practice. Dead space (the volume of gas not participating in gas exchange) can be measured using a single-breath nitrogen washout technique, or by application of the Bohr equation. Dynamic volumes measure airflow through the lungs, and often require individuals to perform a forced vital capacity (FVC) manoeuvre. Data generated from such tests include peak expiratory flow rate, forced expiratory capacity in 1 second (FEV₁) and the ratio FEV₁:FVC, which may be used in the diagnosis, assessment and management of respiratory disease. Flow–volume loops provide more detailed analysis of dynamic airflow in the lungs and are often displayed on anaesthetic machines. Measurement of the maximum voluntary ventilation (MVV) provides a global assessment of respiratory system function because it is influenced by airway resistance, respiratory muscle function, ventilation control mechanisms and compliance of lungs or chest wall. An approximation of MVV can be made by multiplying the FEV₁ by 35.

Keywords: airflow, dead space, flow–volume loops, spirometry, ventilation